From Wikipedia, the free encyclopedia
Chemical compound
Meclofenoxate (INN , BAN ; brand name Lucidril , also known as centrophenoxine ) is a cholinergic nootropic used as a dietary supplement .[2] [3] [4] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).
In elderly patients, meclofenoxate has been shown to improve performance on certain memory tests.[5] Meclofenoxate also increases cellular membrane phospholipids.[citation needed ] It is sold in Japan and some European countries, such as Germany , Hungary , and Austria , as a prescription drug .
Side effects [ edit ]
Meclofenoxate is considered to be safe and high in tolerability . However, possible side effects may include, rarely, insomnia , dizziness , restlessness , muscle tremor , depression , nausea , muscle tension , and headache ; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.
Research [ edit ]
Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 26.5%.[6] [7]
Brand names [ edit ]
In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.[8] In the US, meclofenoxate is sold as a dietary supplement, although it is an unapproved drug.[4]
See also [ edit ]
References [ edit ]
^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16 .
^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies . Springer. pp. 758–. ISBN 978-1-4757-2085-3 .
^ Index Nominum 2000: International Drug Directory . Taylor & Francis. January 2000. pp. 636–. ISBN 978-3-88763-075-1 .
^ a b Cohen PA, Avula B, Khan I (October 2022). "The unapproved drug centrophenoxine (meclofenoxate) in cognitive enhancement dietary supplements". Clinical Toxicology . 60 (10): 1156–1158. doi :10.1080/15563650.2022.2109485 . PMID 35959800 . S2CID 251516603 .
^ Marcer D, Hopkins SM (May 1977). "The differential effects of meclofenoxate on memory loss in the elderly" . Age and Ageing . 6 (2): 123–31. doi :10.1093/ageing/6.2.123 . PMID 329662 .
^ Donaldson T (1 January 2003). "A Brief History of Anti-aging Drugs" . In Klatz R, Goldman B (eds.). The Science of Anti-aging Medicine . American Academy of Anti-Aging Med. pp. 66–. ISBN 978-0-9668937-3-1 .
^ Hothschild R (August 1973). "Effect of dimethylamnioethyl p-chlorophenoxyacetate on the life span of male Swiss Webster Albino mice". Experimental Gerontology . 8 (4): 177–183. doi :10.1016/0531-5565(73)90024-7 . PMID 4147092 .
^ Zhou Y (22 October 2013). Drugs in Psychiatric Practice . Elsevier. ISBN 978-1-4831-9193-5 .
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